Current influenza vaccines only confer protection against homologous viruses. By adsorbing to the air-water interface of alveoli, with hydrophilic head groups in the water and the hydrophobic tails facing towards the air, the main lipid component of surfactant, dipalmitoylphosphatidylcholine (DPPC), reduces surface tension. SURFACTANT 2. •Surfactant that lines the epithelium of the alveoli in lungs is known as pulmonary surfactant and it decreases the surface tension on the alveolar membrane. Pulmonary surfactant is a specialized biological fluid synthesized and secreted by ___ alveolar cells. Pulmonary surfactant is a complex of highly active phospholipids and proteins that cover the alveolar epithelial surface of the lungs 1. Respiratory-distress syndrome of the newborn (surfactant is deficient) Some important facts about pulmonary surfactant. And, best of all, most of its cool features are free and easy to use. According to LaPlaces law, the pressure (P) necessary to keep the sphere open is proportional to the surface tension (T) and inversely proportional to the radius (R) of the sphere, shown by the formula P = 2T/R If … Furthermore, CO2 generates carbonic acid with which the body must continuously deal in order to maintain the proper pH in the internal environment. Pulmonary surfactant (PS) replacement therapy has been established as a safe and effective treatment for immaturity-related surfactant deficiency since the early 1990s. Overview. The lung and the Upper Respiratory Tract -1. It is formed by type II pneumocytes from about 20 weeks of gestation. Pulmonary surfactant is produced by cells within the lungs and decreases surface tension by breaking bonds between water molecules. Primary PAP is led by a granulocyte–macrophage colony-stimulating factor (GM-CSF) signalling disruption; the autoimmune … Do you have PowerPoint slides to share? 1. The surface tension between gaseous- aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant. Pediatr Pathol 1994;14:945-53. A mixture of phospholipids and protein ... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 120db9-NjIzO. The Respiratory System Homeostasis is essential for survival of cells Cells: “Cells need a constant supply of O2 delivered to them to support their energy-generating chemical reaction, which produce CO2 that must be removed continuously. World's Best PowerPoint Templates - CrystalGraphics offers more PowerPoint templates than anyone else in the world, with over 4 million to choose from. Lung Compliance Lung compliance (CL) is a measure of the elastic properties of the lung ... - Mechanics of Breathing Breathing Inspiration: ... A spirometer is used to measure lung capacities and produces a spirograph Lung Capacities Tidal Volume: ... Reversal of Aberrant Cancer Methylome and Transcriptome upon Direct Reprogramming of Lung Cancer Cells. A mixture of phospholipids and protein... – A free PowerPoint PPT presentation (displayed as a Flash slide show) on PowerShow.com - id: 120db9-NjIzO ... RADIOLOGICAL EXAMINATION OF THE LUNG AND PLEURA. Pulmonary surfactant is a surface-active lipoprotein complex (phospholipoprotein) formed by type II alveolar cells. - Introduce additional lung units with mismatch between V and Q ... Hyperventilation defined as PACO2 40. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. We aimed to analyze the compositional changes in the surfactant lipidome in COPD and identify specific lipids associated with pulmonary function decline. The assembly of the surfactant proteins into lamellar bodies is less clear and may proceed via the endoplasmic reticulum and Golgi apparatus to multivesicular bodies before combining with the lamellar bodies (10). 1... VentilationPerfusion Relationships in the Lung. The Basics of Measuring Lung ... A. … Furthermore, CO2 generates carbonic acid with which the body must continuously deal in order to maintain the proper pH in the internal environment. - Lung Mechanics: Theory and Practice I. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. That's all free as well! Many of them are also animated. It is formed by type II pneumocytes from about 20 weeks of gestation. If you continue browsing the site, you agree to the use of cookies on this website. The Respiratory System Homeostasis is essential for survival of cells Cells: “Cells need a constant supply of O2 delivered to them to support their energy-generating chemical reaction, which produce CO2 that must be removed continuously. Clipping is a handy way to collect important slides you want to go back to later. As a result, pulmonary surfactant reduces the surface tension of the liquid lining, decreasing the pressure needed to keep the alveoli inflated and maintaining alveolar stability. Surfactant creates a continuously reforming surface layer There is a significant disturbance of the pulmonary surfactant system in MAS, with a wealth of experimental data indicating that inhibition of surfactant function in the alveolar space is an important element of the pathophysiology of the disease. Surfactant proteins. Pulmonary surfactant is a surface-active lipoprotein complex formed by type II alveolar cells.The proteins and lipids that comprise surfactant have both a hydrophilic region and a hydrophobic region. Surfactant replacement therapy in preterm neonates: A comparison of postmortem pulmonary histology in treated and untreated infants. - Pulmonary Mechanics and Graphics during Mechanical Ventilation Definition Mechanics: Expression of lung function through measures of pressure and flow: Derived ... - New treatment options for lung cancer Lung cancer is a leading cause of death world wide 90% of lung cancer is caused by smoking 20% of patients are suitable for ... - Radiofrequency Ablation of Lung Cancer Andrew R. Forauer, MD FSIR Interventional Radiology Dartmouth-Hitchcock Medical Center I have no financial disclosures (but am ... - Lung cancer Edit Csada MD 08.10.2014. t3. Surfactant is an agent that decreases the surface tension between two media. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. Pathology. We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. They are all artistically enhanced with visually stunning color, shadow and lighting effects. The surface tension between gaseous- aqueous interphase in the lungs is decreased by the presence of a thin layer of fluid known as pulmonary surfactant. According to various pathogenetic mechanisms and aetiologies, PAP is classified as primary, secondary or congenital. Pulmonary surfactant is a complex mixture of lipids and proteins that reduces surface tension at the interface between air and liquid. - Heart/Lung Machine 007 - The Bond Series, | PowerPoint PPT presentation | free to view, Pulmonary Mechanics and Graphics during Mechanical Ventilation. The PowerPoint PPT presentation: "Lung Mechanics" is the property of its rightful owner. - Beautifully designed chart and diagram s for PowerPoint with visually stunning graphics and animation effects. Surfactant reduced both neonatal mortality and pulmonary air leaks by about 50%. Bates, PhD, DSc Research Professor of Medicine Vermont Lung Center University of Vermont College of Medicine. Bronchopulmonary dysplasia Twenty-five Years Later. t2. Northway WH. Bates, PhD, DSc Research Professor of Medicine Vermont Lung Center, - Title: Targeted Therapies for Advanced Non-Small Cell Lung Cancer Author: Can Ozturk Last modified by: CAN OZTURK Created Date: 9/29/2005 4:26:22 AM, Lung Mechanics: Theory and Practice I The Basics of Measuring Lung Mechanics. 1). And they’re ready for you to use in your PowerPoint presentations the moment you need them. Other advantages are that radiography and epifluorescent microscopy of the surface f… Novel insights from an animal model aided the discovery of granulocyte macrophage colony stimulating factor (GM-CSF) antibodies as a pathogenetic mechanism … Physiologic concepts. Surfactant is synthesized in the alveolar type-II cells, stored in the lamellar bodies, and secreted to the alveolar space where it undergoes complex changes 2. Approach to cardiac murmurs and cardiac examination in children, Developmental assessment for medical students, [Mary sheridan] from_birth_to_five_years_children(bookos.org)[1], 7 breastfeeding the premature and the sick term baby. Looks like you’ve clipped this slide to already. Winner of the Standing Ovation Award for “Best PowerPoint Templates” from Presentations Magazine. * Staging 6 M0 = No distant metastasis. Lung Mechanics: Theory and Practice IV Measuring Lung Mechanics in Mice, - Lung Mechanics: Theory and Practice IV Measuring Lung Mechanics in Mice Jason H.T. Surfactant is an agent that decreases the surface tension between two media. Integration of flow. The proteins and lipids that make up the surfactant have both hydrophilic and hydrophobic regions. During lung injury, fibroblasts migrate into the alveolar spaces where they can be exposed to pulmonary surfactant. Smoke exposure is known to decrease total pulmonary surfactant and alter its composition, but the role of surfactant in chronic obstructive pulmonary disease (COPD) remains unknown. B. M1a = Separate tumor nodule(s) in a contralateral lobe tumor with pleural nodules or ... Part 2 Mechanical Properties of the Lung and Chest Wall: Static and Dynamic. Pulmonary surfactant, which is composed of phospholipids (90%) and proteins (10%), is synthesised by type II alveolar epithelial cells.9,10The surfactant molecules are then secreted into the alveolar space, where they line the walls of the alveoli. Boasting an impressive range of designs, they will support your presentations with inspiring background photos or videos that support your themes, set the right mood, enhance your credibility and inspire your audiences. The pulmonary surfactant is produced by the alveolar type-II … Objectives To reprogram non-small cell lung cancer (NSCLC) ... - Measuring Neonatal Lung Volume Advisor: Dr. Bill Walsh Doug Anderson David Lammlein Janine McKinnon, Ambient Air, Airway, and Mechanics of Ventilation, - 7 Ambient Air, Airway, and Mechanics of Ventilation. - surfactant keeps the alveoli inflated 8 2 Types Alveolar Cells: Type 1 Alveolar Cells = Make up wall of the alveolar sacs. It's FREE! PPT – Lung Mechanics PowerPoint presentation | free to view - id: 120db9-NjIzO. Surfactant was the first drug developed solely for treatment of neonates; a major breakthrough in neonatal medicine in the past 35 years. Type II. The pulmonary surfactant is produced by the alveolar type-II … It’s 97% of total lung surface area where most gas exchange occurs. In this method, the surface tension at an air/water interface is directly measured by a small plate attached to an electro balance. Type 2 Alveolar Cells - secrete surfactant Surfactant = substance that decreases surface … Type II epithelial cells synthesize and assemble the lipid and protein components into complexes that are stored as tightly packed membranes in lamellar bodies until secreted into the … Pulmonary alveolar proteinosis is a rare but potentially treatable disease, characterized by impaired surfactant metabolism that leads to accumulation in the alveoli of proteinaceous material rich in surfactant protein and its component. - Restrictive lung diseases Acute and Chronic honeycomb lung Clinical features of IPF Males are affected more often than females. One of the major advantages of this system is that a well-defined monolayer of lipids and proteins can be spread at the air/liquid surface. Clinical : ... Embryology. Pulmonary surfactant has both protein and lipid components. Some new synthetic surfactants containing protein analogues, including CHF5633, have recently been studied. Overview. Lung Mechanics: Theory and Practice III Impedance, - Lung Mechanics: Theory and Practice III Impedance Jason H.T. Toti P, Buonocore G, Rinaldi G, Catella AM, Bracci R. Pulmonary pathology in surfactant-treated preterm infants with respiratory distress syndrome: An autopsy study. Pulmonary administration is widely used for the treatment of lung diseases. The interaction between drug molecules and pulmonary surfactants affects the efficacy of the drug directly. Lung Transplantation: Where Are We in 2011? We examined the effects of Survanta and surfactant protein A (SP-A) on fibroblast growth and apoptosis and on type I collagen, collagenase-1, and tissue … Type 2 Alveolar Cells - secrete surfactant Surfactant = substance that decreases surface … Reason No. Pulmonary endothelial and alveolar epithelial injury permeability edema Surfactant dysfunction Maladaptive repair with mesenchymal cells and proliferative fibroblasts Alveolar edema and proteins are cleared, endothelial and epithelial injury repaired Acute hypoxemia, Increased dead space Venous admixture (V/Q mismatch) Low compliance Pulmonary Bronchoalveolar lavage (BAL) fluid … Anatomic concepts. Direct measurement with a spirometer. Or use it to create really cool photo slideshows - with 2D and 3D transitions, animation, and your choice of music - that you can share with your Facebook friends or Google+ circles. Whether your application is business, how-to, education, medicine, school, church, sales, marketing, online training or just for fun, PowerShow.com is a great resource. Pulmonary surfactant represents a complex mixture of what? surfactants(bovine, porcine, human, synthetic) prenatal induction of pulmonary surfactant and antioxidant enzyme activity by maternal corticosteroid treatment and use of exogenous antioxidants as well as steroid and nonsteroid inhibitors of the pulmonary inflammatory cascade. Or use it to upload your own PowerPoint slides so you can share them with your teachers, class, students, bosses, employees, customers, potential investors or the world. - Lung Transplantation: Where Are We in 2011? Pulmonary surfactant is made by our lungs and decreases the surface tension so we can breathe. PowerShow.com is a leading presentation/slideshow sharing website. Pulmonary surfactant is a complex mixture of phospholipids and proteins that serves to reduce alveolar surface tension. February, 2011 Dale Lien Justin Weinkauf * * * * * * * This figure includes only the lung transplants that are reported to ... - There is currently no completely noninvasive way to assess lung mechanical function in mice ... why chamber pressure varies as a mouse breathes? Introduction Pulmonary surfactant is a complex mixture of phospholipids and proteins that creates a unique interface separating alveolar gas and liquids at the alveolar cell surface, reducing surface tension, and maintaining lung volumes at end expiration. See our Privacy Policy and User Agreement for details. Bates, PhD, DSc Research Professor of Medicine. •Surfactant is a surface acting material or agent that is responsible for lowering the surface tension of a fluid. In your PowerPoint presentations the moment you need them is formed by Type II from! 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